Could Gum Disease Be Linked to Alzheimer’s?
Emerging research is uncovering a surprising connection between Alzheimer’s disease and gum disease.
In a recent study, scientists found Porphyromonas gingivalis — the bacterium behind chronic gum disease (periodontitis) — in the brains of deceased Alzheimer’s patients.
Even more concerning, when researchers infected mice with this bacteria, it not only made its way into their brains but also triggered the production of amyloid beta — the same protein closely tied to Alzheimer’s development.
These findings are adding weight to a new theory: Alzheimer’s may not be purely a neurodegenerative disease, but could also have infectious roots.
As research continues, the link between oral health and brain health is becoming clearer — a reminder that caring for your gums might be more important than you think.
Alzheimer’s Disease May Start in Your Mouth:
The study also uncovered that toxic enzymes produced by the bacteria were found in people who had Alzheimer’s-related brain changes — even though they hadn’t yet been diagnosed with dementia. This suggests the infection could begin years before any symptoms appear.
This discovery could pave the way for new treatment options. One pharmaceutical company, Cortexyme, has developed a compound called COR388, which showed promise in animal studies by reducing both bacterial infection and the buildup of amyloid beta. While human trials are still needed to confirm its effectiveness, the findings highlight just how closely oral health and brain health may be connected.
Scientists remain cautiously optimistic. With no major breakthroughs in dementia treatments for over 15 years, exploring every possible cause — including infections — is essential. Although more research is needed, the potential link between gum disease and Alzheimer’s offers a clear and powerful reminder: taking care of your gums and teeth might help protect your brain for years to come.